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potential of genetic discovery. We have access to extensive biosample collections and use advanced omics technologies and genetic-epidemiological methods on human study populations to identify molecular
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datasets for single nucleotide variants, structural variants, and tandem repeats relevant to FTLD Use cutting-edge bioinformatics software and methods, or develop novel tools when appropriate
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method, can engineer thousands of defined mutations in parallel in a single test tube in yeast. Strains are tagged by DNA barcodes, allowing to efficiently track mutations in cell populations during
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, you will engineer synthetic promoters controlling context-specific gene expression in Arabidopsis. You will develop high-throughput (molecular) phenotyping methods to screen transcriptional activity
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behavior in mice and measure calcium signals in the bladder’s urothelium, its inner lining. We now aim to combine these methods with optogenetics to explore how sensory signaling in the urothelium affects