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Saelens team. Research Project In this research project you will develop probabilistic deep-learning models that automatically extract biological and statistical knowledge from in vivo perturbational omics
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and Saeys teams. In this research project you will develop and apply algorithms to link clinical phenotypes of metastasis to molecular phenotypes in mouse models. It is known that metastases exhibit
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or altered behavioral responses in ASD models How these changes reflect underlying shifts in cortical circuit function You will work within the Bonin and Farrow Labs, which brings deep expertise in
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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understanding on the origin of nucleic acids that are shed in liquid biopsies, such as blood, using cancer models (mouse and rat) and patient samples of neuroblastoma disease, a rare childhood cancer. Nucleic
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drive neuroinflammation in synucleinopathies and other neurodegenerative diseases. The candidate will employ advanced in vivo models and spatial technologies to dissect the roles of tissue-resident
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systems and computational biology. Models include yeast, fly, mouse, and pluripotent human cell systems. Research groups have access to state-of-the-art research and top-notch support core facilities and
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validate the identified key (epi)genetic molecular and explore their therapeutic potential in vitro and in vivo disease models. Profile The candidate should: have an MSc in Systems Biology, Molecular Biology