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mRNA during its translation by the ribosome. This process is exemplified by tubulin mRNAs, which are selectively degraded when cells sense excess free tubulins, the building blocks of the microtubule
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, the mechanisms by which cells sense and regulate mtDNA levels remain poorly understood. Understanding this process is crucial as altered mtDNA levels are associated with various human diseases
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) ranging from hundreds to thousands of molecules. Factors such as ATP demand and nucleotide availability are proposed to influence mtDNA content. However, the mechanisms by which cells sense and regulate
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