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, and dysregulation of R-loop processing is associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins
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associated with cancer and neurodegenerative diseases. We have developed an unbiased mass spectrometry-based proteomics approach to identify proteins that regulate R-loops in human cells and discovered a role
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: Nuclear mRNA export is an essential step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in
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, result interpretation and figure visualization on biological data of genomics, transcriptomics, proteomics, cytomics, spatial omics to identify genetic and cytometric biomarker Provide statistical
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step in eukaryotic gene expression, ensuring that mature transcripts are delivered from the nucleus to the cytoplasm for translation. Multiple challenges are faced in this process: How are mRNAs
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in vivo and in vitro approaches to study maternal mRNA regulation across multiple levels. Zebrafish is our primary in vivo model, offering powerful genetic tools and abundant embryos for applications
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labeling strategies be further developed and optimized for live-cell imaging, super-resolution microscopy, and cell-specific proteomics? How do neurons, glial cells, and immune cells communicate, and how can
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) to ultimately discover novel therapeutic avenues to implement precision medicine in this field. In order to achieve this our group is engaged in multiple projects covering an array of techniques at both in vitro
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University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations
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University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations. Summary