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Apply now PhD Candidate in Chemistry, Proteomics, and Immunology The Leiden Institute of Chemistry is looking for a PhD candidate to pursue research on the development of immune-modulatory drugs
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for their ability to undergo somatic embryogenesis, and then use genome-wide association (GWAS) mapping, transcriptomics and proteomics to identify the quantitative trait loci (QTL) that are significantly associated
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) mapping, transcriptomics and proteomics to identify the quantitative trait loci (QTL) that are significantly associated with the somatic embryogenesis. These approaches will allow us to identify a set of
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, proteomic and cellular changes in SNAREopathy cell models, in induced pluripotent stem cell (iPSC)-derived neurons from SNAREopathy patients. The key objectives for this project are: To upscale and multiplex
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therefore have substantial therapeutic applications. Cellular metabolism is an important mechanism regulating immune function. This PhD project will use a combination of synthetic chemistry, proteomics, and
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synthetic chemistry, proteomics, and biological techniques to elucidate how specific metabolites modulate immune function and to develop synthetic small molecules that can mimic these processes. The candidate
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, building on previous studies in the department that have established genomic, proteomic and cellular changes in SNAREopathy cell models, in induced pluripotent stem cell (iPSC)-derived neurons from
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, organoids and infant GuMI models, metabolomics and proteomics, the goal is to identify beneficial bacterial metabolites and genes that are responsible for immune training. The project is part of NeoGutChip
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at the early stage of our life. Using multi-disciplinary approaches such as anaerobic culturing, synthetic biology, organoids and infant GuMI models, metabolomics and proteomics, the goal is to identify
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proteomics and/or flow cytometry and fluorescence microscopy would be considered an asset, as also previous experience with in vitro cell culture systems, cell biology and/or nanomedicine research. We offer