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encoding cardiac proteins. At the Department of Experimental Cardiology, research focuses on identifying novel disease mechanisms underlying inherited forms of SCD, with the aim of developing new therapeutic
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experiments as well as bioinformatics and advanced imaging techniques. Your core tasks are: Cloning and expressing recombinant proteins. Developing and optimizing purification protocols. Designing and
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maintain robustness through evolution using live-cell imaging and multiscale modelling. Job description Cells are often described as intricate machines where proteins work together in a tightly coordinated
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described as intricate machines where proteins work together in a tightly coordinated fashion to produce essential cellular functions. Yet evolution challenges this picture. Proteins that are crucial for a
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of translation is crucial for controlling protein levels and guiding development. In the Ruijtenberg lab, we study these mechanisms using a combination of genome-wide sequencing and single-molecule imaging
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combine molecular genetics, proteomics, bioinformatics and spectroscopy approaches. We apply this integrated approach to elucidate the function of key proteins in a variety of biological processes
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approaches. We apply this integrated approach to elucidate the function of key proteins in a variety of biological processes. The research in Biochemistry is organised into seven research themes: Redox Cell
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, otherwise healthy individuals and are caused by monogenic defects in genes encoding cardiac proteins. At the Department of Experimental Cardiology, research focuses on identifying novel disease mechanisms
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the information stored in our genome. Especially in germ cells and early embryos, where transcription is absent, regulation of translation is crucial for controlling protein levels and guiding development. In
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for controlling protein levels and guiding development. In the Ruijtenberg lab, we study these mechanisms using a combination of genome-wide sequencing and single-molecule imaging approaches, aiming to understand