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protein-DNA interactions) Produce stable complexes between proteins and/or DNA Determine structures of proteins/complexes Design mutants and perturbations for in vivo experiments Perform in vivo functional
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Your position Biomolecular dynamics, such as conformational changes, are the understudied link between biomolecular structure and function. Single-molecule FRET is an established technique, unique
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in medical applications, this challenge is largely a materials challenge. Existing medical implants are dominated by rigid structures that often lack the adaptability and sophistication required
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nano-scale objects Designing and building a coherent low-energy electron microscope Sample preparation and recording holograms Numerical reconstruction of the sample structure Presenting the results
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enables label-free trapping and sensing of single proteins in solution for up to hours. Now, we leverage the unique abilities of nanopore trapping to detect proteins and their conformations, dynamics
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Perform experiments in PSI laboratories and at synchrotron radiation facilities, data processing and analysis Optimization and automation of reaction parameters, correlation of the structural data with
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-duration energy storage. The approach is to use hierarchical structures, i.e. complex material layers that can be optimized to specific battery chemistries and flow phenomena from the microscale up
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-duration energy storage. The approach is to use hierarchical structures, i.e. complex material layers that can be optimized to specific battery chemistries and flow phenomena from the microscale up
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systems as most biomolecules are chiral and their interactions with other chiral objects are fundamental to many key biological processes. Chiral molecules exist in two forms, a left-handed one and a right
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in solution for up to hours. Now, we leverage the unique abilities of nanopore trapping to detect proteins and their conformations, dynamics, interactions, catalytic mechanisms etc. in real-time