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Ridge National Laboratory) with the possibility of working on a placement. The PhD project will develop software to interface with the high impact and widely used GEANT4 code. A validation of the
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of the produced EVs using high resolution cell imaging. You will investigate the mechanism(s) of any EV-related chemotherapy resistance observed. Finally, you will attempt to target EV production (by CRISPR Cas9
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processes. Your responsibilities will include: Rapid prototype pattern manufacture Production of sand and investment moulds Supporting the melting and pouring processes Finishing of castings, including
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in normal fibroblasts and CAFs. More specifically, the student will aim to: 1. Image ERK, NF-κB and STAT dynamics in response to the application of multiple growth factors in fibroblasts derived from
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A search for pharmacological inhibitors of a cancer-associated adhesion GPCR in the zebrafish embryo
, chemoinformatics and image analysis). The student will gain experience in working with zebrafish embryos, and the use of high-content imaging techniques (fluorescent in situ hybridisation, immunohistochemistry
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professional judgement to see the bigger picture in any project, analyse and develop creative and pragmatic approaches to problem solving, balancing risks and benefits to make recommendations (assessed
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Details ULTRACAM and HiPERCAM are high-speed optical cameras that can take hundreds/thousands of CCD images per second simultaneously in three/five colours, respectively. They have been mounted
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that are applicable to various fields. We are developing fabrication techniques of micro origami-robots and remote magnetic control methods that are to be applied to paradigm shifting manufacturing approaches and in
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secretion from chromaffin cells. Using a combination of patch clamp electrophysiology and live cell fluorescent imaging the interactions between heterotrimeric G protein subunits, their effectors and the
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theoretical, based on matched asymptotic analysis and other perturbation methods, and numerical, i.e. an existing in-house code will be modified to achieve the objectives. This project offers the unique