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Position Summary The Ornitz Lab at WashU Medicine is seeking a highly motivated postdoctoral researcher with experience working with mouse models of development and disease. Candidates will have the
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biochemistry, genomics, molecular genetics, cell biology, and model organism systems to uncover the mechanisms by which histone mutations disrupt human development and lead to disease. Our ultimate goal is to
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immune cells will be studied in preclinical models with special emphasis on how adoptively transferred cells interact with tumor cells, the tumor microenvironment, and resident immune cells. Successful
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) as models. PXR and CAR transcriptionally regulate cytochrome P450 3A4 (CYP3A4) and CYP3A5-drug-metabolizing enzymes that metabolize more than 50% of clinical drugs, the dysregulation of which
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electrophysiology to translational models, including animal studies and analyses of human tissue samples. This full-stack methodology enables us to directly link molecular channel function with disease phenotypes
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., multivariate statistics, linear and generalized linear mixed effects models, PCAs, PCoAs, RDAs, and permutational approaches) of large integrated datasets including ecological, environmental, molecular, and
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mice as model systems and combine molecular, cellular, developmental and bioinformatics approaches to establish how chromatin regulators reshape the epigenome and regulate cell fate during development
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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computational models with microbiome-driven mechanisms and lay the groundwork for studies on microbiome modulation as a therapeutic strategy. Integrating clinical expertise and advanced molecular analyses ensures
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computational models with microbiome-driven mechanisms and lay the groundwork for studies on microbiome modulation as a therapeutic strategy. Integrating clinical expertise and advanced molecular analyses ensures