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of an in vivo rat model to study the impact of biofilm infections on implant osseointegration and generate mutant bacterial strains to investigate the molecular mechanisms of Staphylococcus aureus adhesion
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on microbiological and molecular profiling of human biosamples, obtained from the largest clinical cohort study on hearing implants, will be conducted to identify biomarkers linked to tissue complications. Biomarkers
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through a combination of registry-based epidemiological studies, in vitro modelling of biofilm behaviour, and in vivo investigations of antibiotic pharmacokinetics and efficacy. The project is part of
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