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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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dynamics and tissue morphogenesis during embryo development using cellular, molecular and mechanical approaches. Cell movements underlie tissue patterns and shapes. Using chick embryos as the model system
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have or expect to obtain a first or upper second-class degree in a relevant subject from a UK university, or equivalent standard abroad. Prior research experience, for instance in molecular biology
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communication skills with the ability to work collaboratively. Ideally, the candidate will have a strong background in molecular biology and/or biochemistry. A good knowledge of genomics and the chemistry
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Fixed-term: The funds for this post are available for 1 year. Applications are invited for a Research Associate (Postdoc) to join the Prorok Lab in the Department of Computer Science and Technology
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of these factors. The work will involve genomic, proteomic and molecular approaches to decipher how these proteins contribute to NEPC and to explore if they can be therapeutically blocked. We aim to understand how
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processes associated with CIN [1], leveraging single-cell DNA sequencing understand CIN heterogeneity [2], and development and implementation of machine learning and AI models to imaging data [3]. The student