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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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to “trick” resistant strains into becoming drug-sensitive. This interdisciplinary research combines synthetic biology, molecular biology, and biochemical engineering to pioneer sustainable, non
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). Design and fabricate patterned surfaces optimised for enzyme immobilisation. Assess synergistic antibiofilm efficacy under static and dynamic (flow-based) biofilm models. Apply advanced microscopy, protein
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
for small-molecule sensing. By engineering nanopores with molecular recognition elements such as DNA aptamers, this project will enable multiplexed, real-time detection of diverse antibiotics, supporting both
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Supervisors: Dr Lucy van Dorp Prof Joanne Santini Abstract Phages - viruses that infect bacteria - are rich sources of molecular diversity with potential applications in antimicrobial discovery
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techniques Microbiology and molecular biology Enzymology and antimicrobial screening Training will take place across three state-of-the-art laboratories, with opportunities for collaboration, publication, and
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: Machine Learning Molecular Dynamics. The project involves the development and application of machine learning methods that enable a major boost of the time and length scales accessible to ab-initio/first
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courses and conferences. Research Environment: The Werner and Waudby labs at UCL provide complementary expertise in viral molecular biology, structural biology, and NMR spectroscopy. The student will work
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, numerical methods, molecular biology methods (e.g. cloning, PCR) and bacterial plasmid mating. How to apply This project is offered as part of the Centre for Doctoral Training in Engineering Solutions