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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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of these factors. The work will involve genomic, proteomic and molecular approaches to decipher how these proteins contribute to NEPC and to explore if they can be therapeutically blocked. We aim to understand how
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formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome (e.g. see Genome Biology, 2025 25, 155; Nature Chemistry, 2025, 17, 875; PNAS, 2024, 12(7
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dynamics and tissue morphogenesis during embryo development using cellular, molecular and mechanical approaches. Cell movements underlie tissue patterns and shapes. Using chick embryos as the model system
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screens. Nature Reviews Molecular and Cell Biology 2023. 24, 477-494. Awwad, S.W., Doyle, C., Coulthard, J., Bader, A.S., Gueorguieva, N., Lam, S., Gupta, V., Belotserkovskaya, R., Tran, T-A
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understood. This project will combine molecular, cellular, and physiological approaches to explore how exercise reprograms metabolic and inflammatory pathways that connect cardiac function to systemic health
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technologies, bulk and single-cell RNA-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available
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to symmetry breaks in the patterning process. A hybrid modelling approach integrating the dynamics of a core network while utilising a virtual template from experiments for cellular growth and division will be
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molecular biology. Relevant post-doctoral experience is desirable. High quality peer-reviewed publications and a keen interest in translational regulation are essential. If you have an excellent background in
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Fixed-term: The funds for this post are available for 1 year. Applications are invited for a Research Associate (Postdoc) to join the Prorok Lab in the Department of Computer Science and Technology