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(bacterial, viral, inter-archaeal). - Quantify gene family dynamics (duplication, loss, HGT) by major lineage, and identify evolutionary shifts associated with ecological transitions (thermo/halophily
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and Physical chemistry (ED182) of the Université de Strasbourg. He or she will work in the BIODYN team (“Biophysics and Dynamics of Organic Nanostructures”: a research team led by J. Léonard and S
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, located within the Institute of Molecular and Cellular Biology (IBMC), studies the mechanisms of virus replication and assembly using advanced RNA biology techniques. Dr. Smyth's team focuses
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, including 180 permanent staff (researchers, professors, engineers, technicians, and administrative personnel) and around 180 non-permanent staff (PhD students, postdocs, and fixed-term contracts). Each year
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one species. Secondly, they will explore the evolution of this molecular complex (or single nuclease) across nematode species to understand its origin. In parallel, they will analyse the dynamics
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carried using explicit water molecules relying on molecular dynamics (thermodynamic integration and/or metadynamics). The screening for improved catalysts compared to the state-of-the-art (Pt-Ru) will start
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of quantum technologies and materials synthesis. Dynamism and determination are essential for success in this research. Techniques and Methods The project will involve a multidisciplinary approach combining
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be done via computer simulations, including Monte Carlo and molecular dynamics, combined with the use of statistical mechanics to predict e.g. phase transitions, nucleation rates, etc. The work will be
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-permanent staff (doctoral students, postdocs, associate researchers and interns). The ICS has characterization platforms (UV-Vis and IR spectroscopies, size exclusion chromatography, light scattering, etc
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understanding of the mechanisms that support their development in humans is therefore of major therapeutic interest. The aim of the thesis project is to decipher the cellular and molecular mechanisms supporting