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, connections to diverse cellular processes and repurposing for the export of non-canonical mRNAs remains cryptic. PhD Project: “Mechanistic insights into novel mRNA export complexes” During my postdoc I
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interaction that affects HSC output in aging. This will be achieved via the implementation of state of the art multicolor flow cytometry analyses, imaging, omics techniques (e. g. single cell sequencing and
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) are important mediators of most cellular processes. Understanding how proteins interact with each other, ideally at structural resolution, is key in understanding molecular processes, how disease mutations would
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is
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longer-term immune responses. Specifically, they play key roles in pathogen recognition, antigen uptake, processing and presentation, but also contribute to tissue homeostasis, tolerance to commensal