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products (e.g. transcripts and proteins) and imaging analysis. The roles of relevant parasite genes and pathways are investigated using gene expression perturbation approaches, such as RNA interference and
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vitro and cell-based approaches. In this endeavour the position is for a Postdoc with expertise in cell signalling pathways, protein biochemistry and in vitro cell biology. You will be responsible
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biological, and live cell fluorescence imaging experiments. Associated structural analysis of the proteins by cryo-electron microscopy will be undertaken via collaboration with other workers. This full-time
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, calcium imaging, optogenetics and/or behavioural methods. The project is part of a broader research programme designed to use cross-species research to uncover mechanisms for memory in both health and
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-on experience in at least one of single-cell or spatial omics, imaging, or other high-dimensional biological data types. You interrogate existing literature critically, design rigorous experiments and deliver
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paradigm shift in our fundamental understanding of the charge-lattice interactions that govern such effects. This PDRA role will utilize several state-of-the-art spectroscopic techniques, such as transient
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cancer biology, molecular biology, medicine, or neuroscience. Your expertise will include molecular biology techniques, advanced microscopy, quantitative image analysis, and primary tissue culture, all
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cultures. Experience in molecular biology methodologies, following and adapting protocols and setting up cellular assays including image-based is essential for this role, and knowledge of neuroinflammation
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group aims to determine regulatory pathways affected by disease by implementing the use of spatial proteomics combined with transcriptomics and live imaging. The total proteome of a neuron includes a vast
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to target specific transcription factors (iii) use of high content imaging and AI to phenotype these cultures (iii) use of bulk and single-cell RNAseq to characterise the transcriptional profile of each cell