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Primary supervisor - Dr Amr El-Demerdash Many natural products (NPs) show remarkable biological activity, yet their clinical potential is often limited by poor solubility, metabolic instability
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compare host responses to infection across distantly-related land plant lineages. The goal of this project is to explore the delicate balance between disease resistance and susceptibility to filamentous
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Primary Supervisor - Dr Lidong Be Scientific Background One of the key challenges in volcanology is understanding changes in volcanic activities during crises, such as transitions from effusive
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modifications affect topoisomerase activity during C. elegans nervous system development. This multidisciplinary project provides advanced training in molecular genetics, genomics, and translational biotechnology
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. For example, the food-safe plastic PET is found throughout the terrestrial ecosystem, where it can persist for decades. Biodegradation has great potential as a cost-effective, environmentally friendly solution
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contributors to obesity and liver steatosis, where lipid accumulation becomes toxic for hepatocytes leading to cell death and consequent inflammation. Autophagy, which removes intracellular components, is key
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Primary Supervisor - Prof Kate Kemsley Scientific Background Deforestation is a major global issue, destroying biodiversity and accelerating climate change by removing vital carbon sinks. The newly
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% efficient in this process largely due to proton leak pathways that occur, leading to energy lost as heat. In specialised brown adipose tissue, popularised as ‘good fat’, such heat production is specifically
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Primary Supervisor - Dr Stefan Bidula Scientific background Dimethylsulfoniopropionate (DMSP) is a stress molecule produced by marine organisms such as phytoplankton, algae, corals, and some plants
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, the race is on to understand how these DNA changes affect disease progression and post-operative recurrence risk. This PhD project uses CRISPR/Cas9 to examine risk variants in patient-derived cells and