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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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. Approach and Methods: Apply deep learning-based modelling and clustering to analyse a curated dataset of hundreds of thousands of UL-CDR sequences Characterise sequence–structure relationships and structural
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-penetrating capabilities Evaluate delivery efficiency in cell-based models mimicking lung and immune tissues Identify structure–function relationships to inform rational design of future mucosal delivery
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(SONATA, EP/V028626/1) and brings together expertise in microfluidics, fluid dynamics, nanoparticle engineering, and dental microbiology. Approach and Methods: Engineer in vitro models of bacterial biofilm
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refer to the following website for eligibility criteria: https://www.ucl.ac.uk/prospective-students/graduate/research-degrees/physics-and-astronomy-mphil-phd . The studentship will cover university fees
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of industry and healthcare partners, a rare opportunity to develop a highly sought-after interdisciplinary skill set that is in demand across both academia and industry. Training and Student Development
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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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techniques. The findings will lay the groundwork for clinical application and contribute to the development of targeted therapies for resistant bacterial infections. Approach and Methods Atomic force
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within a highly collaborative setting, benefiting from access to the UCL Automation Network and cutting-edge facilities for structural and biophysical analysis. The project is well-positioned to deliver
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-pharmacological antifungal therapies. Approach and Methods: Develop and optimise laboratory models of fungal growth and resistance. Investigate how environmental stress factors (e.g. osmotic and nutrient stress