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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular
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microenvironment to weaken resistance mechanisms and enhance the efficacy of existing treatments. By manipulating stress responses in fungi such as Saccharomyces cerevisiae and Aspergillus nidulans, the project aims
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will uncover the interfacial solvation structure, validated through comparison between computed and experimental sum-frequency vibrational spectroscopies, as well as the mechanism of chemical
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mechanisms to guide the design and formulation of nanoparticles with superior drug delivery properties. Investigate the interaction between ultrasound, nanoparticles, and biofilms to assess antimicrobial
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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such as, but not limited to, chemical, pharmaceutical, biochemical, or mechanical engineering; pharmaceutical sciences; materials science; or related areas. Applicants from computer science with relevant
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and AMR markers. By integrating plasmonic signal amplification using gold nanostars with a power-free electrokinetic focusing mechanism, the device will enable early-stage detection without the need