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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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(Chemistry) and Michalska (Mechanical Engineering) groups lead research at the interface of chemistry, materials science, and engineering. The student will join a vibrant, collaborative ecosystem tackling AMR
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annually, with life-threatening consequences for immunocompromised individuals. With few antifungal drugs available and resistance on the rise, this project explores a novel strategy: engineering the fungal
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Eastman Dental Institute. Research Environment: The student will join a vibrant, multidisciplinary research community within UCL’s Mechanical and Chemical Engineering departments. The project is supported
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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and AMR markers. By integrating plasmonic signal amplification using gold nanostars with a power-free electrokinetic focusing mechanism, the device will enable early-stage detection without the need
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such as, but not limited to, chemical, pharmaceutical, biochemical, or mechanical engineering; pharmaceutical sciences; materials science; or related areas. Applicants from computer science with relevant