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characterization using cryo-electron tomography (cryo-ET), and complementary light microscopy methods. Specific objectives are: Setting up cryo-ET FIB SEM workflow for reconstituted synapses Visualize nanoscale
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Integration of macroscopic (magnetic resonance imaging) and microscopic (multi-cell microscopy) brain phenotypes with single-cell transcriptomics; o Predictive modelling of late-life dementia from midlife
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for cryogenic electron microscopy (cryo-EM), light microscopy, sequencing, and proteomics. For more information, please visit https://www.helsinki.fi/hilife/bi Where to apply Website https
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Field Engineering » Materials engineering Engineering » Computer engineering Engineering » Aerospace engineering Engineering » Mechanical engineering Computer science » Autonomic computing
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Biology or related field; research experience in one or more of the following protein purification, protein-nucleic acid biochemistry, cryo-electron microscopy and/or structural biology; Fluent in
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provide hands on support in tasks related to mouse experiments, molecular biology and cell culture. Profile The candidate: Should have a (professional) bachelor’s degree, Master’s or PhD degree in
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, protein biochemistry, electron and fluorescence microscopy and CRISPR/Cas9 genome editing to study the role of the early autophagy machinery in targeting and degrading protein aggregates and organelles
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specimens for microscopy essential but could be taught. Additionally, assistance to the PI (MD) and a research scientist (Phd) in grantwriting and manuscript writing may be asked. QUALIFICATIONS: Minimum 2
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elucidation of membrane protein complexes and integrates fundamental cell biology and structural biology by cryo- electron microscopy. The lab has a strong track record in investigating scramblases and their
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assays/ techniques (RNA, DNA, and protein extraction; real-time qPCR, Western blotting, cell-function assays, ELISA, immunofluorescence staining, confocal and transmission electron microscopy, and flow