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a family of specific peptide substrates for the PKs of interest (PKs of the JAK, GRK, IRAK, RIPK and ERK/MAPK families) (2) developing and optimizing fluorescent peptide biosensors from the identified
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optimize a multimodal pretargeted radionuclide therapy approach for PDAC, leveraging the simultaneous targeting of both neoplastic and stromal targets to enhance therapeutic outcomes and reduce associated
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human cells and tissues. 1. Perform research, from experimental design and implementation to the writing of results: • Analyse the scientific literature for the project. • Design and optimize DNA
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cavitation and the effects observed on biofilms and bacteria, and to understand these links, in order, in the long term, to optimize and control this type of therapy. The profile of the PhD student (M/F) must
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the structure of the BMP1/PCPE2 complex by cryo-electron microscopy with the help of previously developed Nanobodies® to stabilize flexible regions. Finally, we will engineer an optimized inhibitor of BMP1 with
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of the main technical challenges associated with each pattern. - You will develop these proxy apps by leveraging the libraries, frameworks, and tools provided by the other NumPEx teams. - You will optimize
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accelerate Europe’s energy transition. This ambitious goal will be achieved by developing advanced experimental and computational tools to characterize e-fuel combustion processes, optimize fuel-flexible
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systems and accelerate Europe’s energy transition. This ambitious goal will be achieved by developing advanced experimental and computational tools to characterize e-fuel combustion processes, optimize fuel
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, to understand particle formation and defect incorporation mechanisms. 2. Optimize the optical properties of G4V-NDs via original post-synthesis treatments, with in situ testing at the SOLEIL synchrotron