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Primary supervisor - Dr Amr El-Demerdash Many natural products (NPs) show remarkable biological activity, yet their clinical potential is often limited by poor solubility, metabolic instability, or toxicity. These issues stem from the rigid, hydrophobic, and synthetically challenging frameworks...
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solve complex problems from theory to decision making, combining several disciplines (e.g. economics and applied sciences). A candidate with strong statistical/mathematical knowledge and experience
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(Beraza and Rushworth) whose work have a strong translational aim. This team will train the PhD student in a series of preclinical in vivo models; molecular biology and immunology methodologies; and complex
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the polar diatom Fragilariopsis cylindrus. This work will be done at UEA and IOCAS. To label the two ppRHO variants for TEM, synthetic peptides matching the C-termini have already been synthesized. A diatom
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Primary Supervisor - Prof David S Richardson Scientific Background Genetic variation within populations is essential to their ability to adapt and survive, but most mutations that change function
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the variation needed for species to adapt to new environments. Recent work from the supervisor’s lab has, for the first time, revealed consistent sets of sexually antagonistic genes in the fruit fly Drosophila
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design, in planta assays, and plant pathology. There will opportunities to work with national and international collaborators. The student will receive expert training in diverse disciplines on a
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sequencing, bioinformatics, fieldwork, and statistical analysis. Health and performance decline with age in humans and other animals, but the consequences for offspring of older parents remain unclear. Since
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Primary supervisor - Dr Rose Davidson Dupuytren’s disease bends the fingers irreversibly into the palm, threatening employment, selfcare and independence. Despite its prevalence, Surgery temporarily
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in stress responses and ageing, we want to understand this protein’s functions at the lysosome, to define a novel role for PrLPs in determining stress resistance through effects on lysosome function