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Abstract: Medical device-associated infections (MDAIs) are a major clinical and economic burden, particularly in orthopaedics where implant-related infections can lead to severe complications, including
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. This project will use large-scale metagenomic mining to uncover novel phage-host associations and identify phage-encoded enzymes, such as endolysins, with antibacterial activity. By integrating evolutionary
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pharmaceutical R&D Application of AI in process development and materials discovery Antimicrobial testing and biological evaluation Workflow integration and data management for self-driven laboratories Project
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for external instrumentation. This dual amplification strategy offers a transformative approach to point-of-care diagnostics, with potential to improve antimicrobial stewardship and patient outcomes in community
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PhD Studentship: Nanopore Technology for Rapid and Accurate Measurement of Antibiotic Concentrations
their use in field or point-of-care settings. This project aims to develop portable, nanopore-based sensors for the rapid and accurate quantification of antibiotic concentrations in environmental and clinical
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Supervisors: Dr. Michele Crotti Dr. Martyna Michalska Abstract: Biofilm-associated infections account for nearly 80% of human microbial infections and are notoriously resistant to antibiotics and
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, reduce the need for systemic antibiotics, and mitigate the development of AMR in oral pathogens. The approach may also be extended to other biomedical applications involving biofilm-associated infections
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targeting AMR gene suppression AI-driven genome design: Use LLM tools (e.g. PlasmidGPT, Evo2) to refactor plasmid genomes for enhanced manufacturability, safety, and performance Microbial validation: Test
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Jochen Blumberger at the Condensed Matter and Materials Physics Laboratory, University College London, UK. Interested candidates may want to work on one of the following two projects. Project 1
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. The work will contribute to pandemic preparedness and the development of next-generation antiviral strategies. Training and Student Development: The student will gain multidisciplinary training in