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independent projects during their training. The Barefield lab uses mouse models and human induced pluripotent stem cell derived cardiomyocyte models of genetic cardiovascular disease to study contractile
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to projects using cutting-edge molecular, cellular, and spatial profiling approaches to dissect vascular and immune signaling across injury models. Key technologies and methodologies include: · Single-cell RNA
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approach, moving from discoveries in human postmortem brain to experimental models in mice. Recent work from our Lab identified disrupted RNA editing as a novel mechanism underlying several neuropsychiatric
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conduct groundbreaking translational research centered on human disease biology. Additionally, we utilize ex vivo multicellular organoid culture models and in vivo disease modeling in mice to enhance our
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the cytoprotective response pathways in oligodendrocytes in vitro, in a variety of genetic mouse models as well as in mouse models of demyelination. The candidate will be involved in several different aspects