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-cell RNAseq datasets and analysis tools, large high-dimensional flow cytometry phenotyping panels and a collection of transgenic mouse models specifically engineered for the reporting, lineage tracing
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as well as in aging mouse models. Identification of these interactions could provide new approaches to counteract or delay age associated exhaustion of HSC. PhD Project: Contribution of cellular
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aging in Cockayne syndrome (CS) patients. Chromatin serves as a platform for DNA repair and undergoes dynamic changes during the DNA damage response (DDR) through the Access-Repair-Restore model. Histones
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model systems zebrafish and fruit fly, and structural biology (including AlphaFold predictions and cryo-EM), we will dissect the roles of these novel mRNA export regulators and define how they interface
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now allow us to study physically interacting cells to define a temporal interactome. In this PhD project, developing these tools in in vitro explants, in vivo models and patient samples of type 2 immune