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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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situ, with direct structure determination, and (ii) investigating and optimizing methods for chirality determination using electron crystallography. Candidate We are looking for a highly motivated and
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. Current Mass Spectrometry approaches have been unable to assess most of the FOXA1 protein for PMTs, but new Mass Spectrometry methods such as 'top-down' approaches permit an unprecedented opportunity
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of our approach is the innovation of novel methods to investigate genome function. For example, we have recently developed ways to map the binding of nucleic acid-interacting drugs and small molecules
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both sites. The project sits at the interface of cell line engineering, protein science and machine learning and you will receive advanced training in these areas while developing methods to accelerate
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Ascl1 are important. We have undertaken a comprehensive discovery experiment to identify all the proteins that can physically interact with Ascl1, using a method we developed called RIME (Rapid
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on the research topic and relevant methods. By the second half, the candidate will take on a leading role and begin carrying out the research comprising their doctoral dissertation. The candidate is expected