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include 1) a murine (diet-induced obesity) model, 2) acute and chronic exercise paradigms, 3) treatment with peripherally restricted enzyme-based eCB modulators, 4) multi-tissue molecular analyses and 5
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-causing mutations. Finally, we will validate the identified key (epi)genetic molecular and eplore their therapeutic potential in in vitro and in vivo disease models. Profile The candidate should: have an
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short and long-read sequencing and transcriptomics, and iPSC-based disease modeling to better understand the genetic etiologies of intractable epilepsy. The team is part of the European STXBP1 consortium
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, will serve as input to generate a statistical prediction model, that will be built together with the bioinformatics team. You will publish scientific articles related to the research project, disseminate
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biological and CRISPR/CAS9 technologies and organoid models derived from CRC patients. You will publish scientific articles related to the research project and will participate to scientific conferences