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into the genomics of population structure and speciation in the Malawi cichlid genus Labeotropheus. This post will build on past work in which over 1000 samples of Labeotropheus from multiple species/populations have
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methodologies to detect and deconvolute the mutational processes associated with CIN [1], leveraging single-cell DNA sequencing understand CIN heterogeneity [2], and development and implementation of machine
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[Nature Biotechnology 2023, 41 1265], as well as novel approaches for the genome sequencing of modified bases and are exploring further base modifications, and how they interact with chromatin proteins (e.g
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hundreds of samples from multiple independent marine transmissible cancer clones. The role provides an exciting opportunity to combine single-cell cancer genomics with molecular cytogenetics and statistical
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mammalian cell culture, cell transfection, multiple omic approaches including processing of tissues for single cell RNA sequencing, drug discovery, western blotting, and immunohistochemistry among other
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-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available, depending on the skills and preference
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presence by creating content that connects with a broad audience. They will draft and review documents before publication to ensure clarity, alignment, accessibility, and alignment with the ARC's core values
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computational support to group members in analysing single-cell RNA sequencing data sets for probing T-cell receptor - peptide interactions. We are an interdisciplinary group focused on applying mathematical
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samples and data. The project integrates whole-genome sequencing, transcriptomics, epigenetic profiling, and clinical information to uncover the key molecular drivers that underpin tumour progression and
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for small-RNA sequencing Bioinformatics analysis of small RNA sequencing data Preparing EVs for in-vitro labelling and uptake experiments High-content imaging of cellular morphology and immunochemistry