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sequencing, and mass spectrometry. With multidisciplinary research teams and a dynamic setting, the IBMC offers a stimulating environment conducive to scientific innovation. The IBMC is also affiliated with
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activity (2, 3). This finding was unexpected because PCPE1 and PCPE2 are very similar in terms of sequences and structures. Objectives The main objectives of the PhD project will be (i) to elucidate
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, the PhD student will have at his/her disposition a set more than 150 high quality genomes (assembled from long-read sequencing and polished with short-reads), more than 100 of P. destructans and more
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the T4SS, test it through functional assays, and validate it using structural approaches. Main tasks Perform genetic constructions (cloning, mutagenesis, sequencing validation) and functional bacterial
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aims to provide an integrated assessment of urban vegetation from multiple perspectives, including its social functions and usage requirements, the ecosystem health of green spaces linked to plant
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. Good command of biostatistics (database management, use of R software) as well as an excellent level of English are essential. As eDNA data are amplified and sequenced independently, the involvement
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proteins (RIME) in a context where PRDM9 is present or absent, and the genomic localization of its known co-factor REC114 will be studied by ChIP followed by NGS sequencing. For a better mechanistic insight
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for the identification of antibiotics-associated proteins and antimicrobial peptides Perform and support experimental studies across the METAMIC project, including notably metagenomic sequencing of field study samples
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of gains and losses of the motif sequence found at chromosome breakpoints using our collection of well-assembled genomes at different evolutionary scales (haplotypes, strains, and species) via bioinformatic
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methods for single-cell data analysis (tools developed by the team : https://github.com/cantinilab ). Single-cell high-throughput sequencing, extracting huge amounts molecular data from a cell, is creating