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that conjugating siRNAs to peptides that bind receptor X will enable targeted delivery of disease-modifying agents directly to affected joint cells. This project will: 1. Identify optimal siRNA sequences
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; and (4) utilise adaptive laboratory evolution (ALE) to enhance the growth of genetically engineered strains and identify mutations using genomic sequencing. Applicants must hold a degree in a relevant
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methodologies include cell culture, analysis of DNA damage and repair by microscopy and RNA-sequencing for splicing analysis. Main Duties The responsibilities may include some but not all of the responsibilities
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use computational approaches to mine natural biodiversity in gene sequences to identify engineering targets to increase lipid content and enhance the water use efficiency. The project will make use
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molecular weight in preparation for genome sequencing. The post holder will also be responsible for some laboratory management roles, including ordering reagents. You will hold a first degree, together
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sequencing technologies. The successful applicant will be expected to lead independent research aligned with the objectives of the BBSRC-funded project and work closely with the PI, Dr Jungnam Cho, and his
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will combine 2 and 3D cell culture systems, gastruloids development, FACS drug screening and next-generation sequencing with investigation of patient samples, to identify and characterise targetable
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-scale data analysis, and systems modelling. The post holder will play an integral role in experimental design, sequencing, data interpretation, manuscript preparation, project coordination, and the
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and manuscripts for peer-reviewed journals. Develop Grant Proposals: Craft compelling funding proposals aligned with Indigenous health research priorities. Conduct Literature Reviews: Synthesize
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, will study the drivers of relapse in acute myeloid leukaemia (AML) with the goal of improving treatment options in this poor outcome cancer. You will perform and analyse next-generation sequencing