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at diagnosis and relapse, and compare them to healthy hematopoietic specimens using nanopore-based direct tRNA sequencing. Complementary transcriptomic, proteomic, and metabolomic profiling will be performed
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validation, and regulatory reporter assays. Learn more about the group here . YOUR MISSION: Investigate how genetic variants affect male reproductive function Perform single-nucleus and bulk RNA sequencing
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- and long-read sequencing; computational and statistical analyses; a good mechanistic understanding of how cells replicate their DNA and respond to DNA damage. We Offer: Excellent framework conditions
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project TARGET-AI will bring together expertise from multiple research groups to advance the state-of-the-art in combining the most advanced techniques from deep learning/AI with rigorous statistical
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the era of large population size and dense genomic data such as whole-genome sequencing, new algorithms are needed to remove the bottleneck of computational load for such a development. In the frame of a
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and molecular tools (e.g., 16S rRNA gene sequencing, metagenomics, and metatranscriptomics). These interdisciplinary studies will further reveal if surfactants from glyphosate application can have
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Collaborative Doctoral Project (PhD Position) - AI-guided design of scaffold-free DNA nanostructures
-based digital twin, which can predict the assortment and sequence of two-dimensional all-DNA motifs required for the engineering desired tessellation patterns at the nanometer scale. We will use available
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Gene expression modulation CRISPR/Cas9 (including knock-out, knock-in, CRISPRa, CRISPRi, viral vector systems) Next-generation sequencing (RNA-, ATAC-, ChIP-Seq, CUT&RUN, Hi-C and others) Pulldown and
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single cell sequencing analyses of mouse and human bone marrow cells at leukemia onset, throughout the course of treatment and upon relapse. Ideally, the candidate brings in strong expertise in cell
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analysis, next-generation sequencing, and small animal models. Salary and social benefits will be determined by the regulations of the German TV-AVH (salary agreement for public service employees