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! Throughout the project, there will be multiple opportunities for cooperation with internal and external partners, supervising Master students, giving oral presentations at conferences, writing high-impact
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, sample and data analysis and write-up of results for scientific publication are part of the PhD process – a journey to become an independent researcher! Throughout the project, there will be multiple
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– a journey to become an independent researcher! Throughout the project, there will be multiple opportunities for cooperation with internal and external partners, supervision of Master students, giving
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technique. If successful, this could pave the way to nano-optical read and write heads for future data storage as well as to direct sequencing of nucleic acid and protein sequences by scanning-probe Raman
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validation, and regulatory reporter assays. Learn more about the group here . YOUR MISSION: Investigate how genetic variants affect male reproductive function Perform single-nucleus and bulk RNA sequencing
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at diagnosis and relapse, and compare them to healthy hematopoietic specimens using nanopore-based direct tRNA sequencing. Complementary transcriptomic, proteomic, and metabolomic profiling will be performed
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Gene expression modulation CRISPR/Cas9 (including knock-out, knock-in, CRISPRa, CRISPRi, viral vector systems) Next-generation sequencing (RNA-, ATAC-, ChIP-Seq, CUT&RUN, Hi-C and others) Pulldown and
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project TARGET-AI will bring together expertise from multiple research groups to advance the state-of-the-art in combining the most advanced techniques from deep learning/AI with rigorous statistical
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assays, flow cytometry, fluorescence imaging, RNA sequencing and biochemical techniques e.g. western blot, quantification assays). Combining diet treatments, pharmacological inhibition and genetic
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single cell sequencing analyses of mouse and human bone marrow cells at leukemia onset, throughout the course of treatment and upon relapse. Ideally, the candidate brings in strong expertise in cell