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), consisting of the partial destruction of chromosomes in their soma during development. Although described as early as 1887, PDE has remained mysterious due to the limitations of model systems and sequencing
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stakeholders, including hardware vendors and research communities focused on emerging technologies, to ensure the project's success and alignment with broader research goals. You will prepare and present
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alignment with broader research goals. You will prepare and present research findings at academic conferences and in peer-reviewed journals. You will mentor other junior researchers and PhD students involved
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, project partner). Activities Conduct research aligned with the mission, covering the scientific fields listed below. Job Constraints The position requires close collaboration with several project partners
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the biomechanical properties of animal and plant biological tissues. - activities: # Develop and validate MRI sequences dedicated to MRE on the 9.4 T scanner and adapt them to 3 T systems (horizontal preclinical and
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: - Start by familiarizing with existing research and methods for genome interpretation (GI NNs, LMMs, GWAS). - Familiarize with the sequencing data - Develop and benchmark MENN prototypes on sequencing
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pediatrics. It relies on a large cohort of children to perform exome sequencing and clinical phenotype analyses, with the aim ofimproving the screening and management of these pathologies. Ultimately
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cell biology experiments (cell culture, transfection, genome editing, etc.) • Preparing libraries for high-throughput sequencing (RNA-seq, Nanopore sequencing, etc.) and using bioinformatics tools
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will be to generate the mitogenomic data and, then, to integrate and analyze all datasets. -- Generation of mitogenomic data (high-throughput sequencing and bioinformatic analyses) -- Phylogenetic and
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-epithelial crosstalk in colorectal cancer initiation, progression and therapy resistance. Using state-of-the-art single-cell RNA sequencing (scRNAseq) and spatial transcriptomics on CRC patient samples, we