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the genetic and molecular basis of adaptation. Recently, our research group developed a groundbreaking CRISPR/Cas9 method called SYNCAS (https://doi.org/10.1016/j.ibmb.2023.104068 ), which enables efficient
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acquired and heritable disorders, by using PXE as a model. Indeed, PXE presents many of the molecular and treatment challenges which are common in ectopic calcification: i) many of the variants found in
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