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the molecular signatures of proteostasis loss and identify early markers of proteostatic failure. The role combines wet-lab spatial biology with computational approaches. You will work across models and scales
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, at Harvard Medical School studies the molecular basis of sensory transduction, using cryo-electron microscopy (cryo-EM), electrophysiology, calcium imaging, computational modeling, and behavioral experiments
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leading cancer research centres, supporting cutting-edge work into the molecular mechanisms of cancer development. As well as core support from Cancer Research UK, the Institute also receives an additional
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multidisciplinary experience in combining integrative computational immunology – data-driven, state-of-the-art single cell resolution and spatial methods, machine learning and kinetic modeling – with integrative
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in mouse models of infection. In addition, will be responsible for the studies involved in evaluating new candidate host-directed therapies for immunomodulatory activity that result in better control
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be studied in vitro throughout epithelial cell invasion using a human digestive epithelium model from CD patients and healthy subjects, and, in vivo in a mouse model of digestive inflammation with
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procedures This role performs various assays, imaging experiments, and other technical duties to assist with the research activities of the laboratory and may be required to work with animal models and/or
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tumors. By leveraging molecular biology, genetically engineered mouse models, and cancer genomics, you will contribute to research aimed at understanding tumorigenesis, treatment resistance, therapeutic
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The ultimate objective of the work in my laboratory is to understand the cellular and molecular basis of vertebrate embryonic induction, with a special emphasis on germ layer and organ formation. Toward this aim
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gene editing, single cell RNA sequencing, bioinformatics, genetic engineering in mice, intravital microscopy and other imaging modalities, and a number of cell and molecular techniques. For more