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understanding the cellular and molecular mechanisms that govern normal and pathologic cell states in neurological and gut disorders. This position will work with animals. ESSENTIAL FUNCTIONS Isolate primary cells
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molecular mechanisms that could be targeted to develop new therapeutic approaches. Regulation of mitochondrial dysfunction, amyloid beta pathogenesis, tauopathy, and TDP-43 pathology are key areas
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and contribute preliminary data, background and significance and experimental design for grant proposals. The focus of the current position is acute myeloid leukemia. Goal is to discover novel molecular
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inflammation-induced cancer. Goal is to discover novel molecular mechanisms that could be targeted to develop new therapeutic approaches. Cytokine and TLR signaling induced activation of NF-kB transcription
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molecular mechanisms that could be targeted to develop new therapeutic approaches. Regulation of cellular signaling by hexosamine biosynthetic pathway, O-GlcNAcylation and NF-kB transcription pathways are key
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. Working experience using transgenic/knockout and xenograft mouse models, Cell Signaling and basic molecular biology techniques is valuable; familiarity with CRSPR/Cas9, cancer stem cells, bioinformatics