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have developed a human ‘brain-on-a-chip’ model that faithfully recapitulates the neurovascular unit, where neurons interface with the vasculature in the brain. You will use CRISPR gene editing
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interdisciplinary training, suitable for candidates from biochemistry, molecular biology, computational biology, chemistry, or data science backgrounds. You will gain experience in: Molecular modeling, QM/MM & MD
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structural biology), Moebius (host–virus evolution, mathematical modelling), and Verkade (correlative microscopy, VolumeEM), the student will be trained in cutting-edge techniques, including cryo-electron
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provide highly sought-after training in the fields of computational molecular modeling, medicinal chemistry, and machine learning. As such, this project is ideal for a candidate with ambitions towards a
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integration into neural circuits to result in functional, restored behaviour. We will use the fruit-fly Drosophila as a model organism for its powerful genetics and molecular cell biology (e.g. CRISPR/Cas9 gene
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recombination, maintaining genetic linkage of toxin/antitoxin-like systems. As a result, these chromosomes accumulate deleterious mutations that are unaccounted for in existing gene drive models. The student will
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for the rapidly developing quantum technologies. Quantum-optical measurements become especially intriguing in systems such as atomic ensembles or molecular processes whose quantum nature remains unclear. These open
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invertebrate model organisms has also suggested that improved ECM function is a key means by which molecular pathways that extend longevity improve age-related health. These studies have suggested that targeting
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science, to deliver molecular mechanics force fields that bridge the gap to quantum mechanical accuracy for biological modelling and computer-aided drug discovery. They will develop electrostatic embedding
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the genetic, molecular, cellular, and whole systems level. Cross-cutting strengths lie in our world-leading expertise in neuroplasticity, interdisciplinary neuro-immune research, high-throughput sequencing