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improvements of the lives of a huge number of men. Techniques and skills training During the PhD you will become an expert in a range of molecular biology, biochemistry, cell and cancer biology techniques
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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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scattering with computer modelling such as molecular dynamics simulations and AI-assisted data mining. The new technical capabilities will help bridge the current gap in biocide development, i.e., to link
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, gather relevant data for modelling, and ensure accurate data collection. Conduct comprehensive bioinformatic analysis utilising established methodologies and tools (e.g. R, Python, MATLAB and other
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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II during transcription and how they control biogenesis of ncRNA and contribute to gene expression regulation using state-of-the-art genomic approaches (Aim 2 and 3). The lab employs several model
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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Description DC6: Molecular and tissue determinants of adverse tissue outcomes in hearing implants. Join the prestigious Marie Skłodowska-Curie Actions (MSCA) Doctoral Network SHIELD (Strategies for Healing
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cells or the tumor microenvironment reduces tumor growth and extends survival in preclinical models, underscoring their potential as dual-function therapeutic targets. To address this, we aim to develop