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Field
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microenvironment. The project will employ genetically engineered mouse and human glioma models, along with advanced imaging techniques, single-cell and spatial transcriptomics, and molecular biology approaches
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increased risk of cardiovascular complications. Using molecular and genetic techniques in transgenic murine models, MPN patient-derived induced pluripotent stem cell lines, and primary patient samples, we
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proteins on brain circuits controlling puberty and fertility are a key focus. Research is conducted in mouse models, addressing the interaction of hormones and neuropeptides in coordinating the brain’s
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advance regenerative medicine. For more information about the lab, please visit https://mesa-lab.org/. Projects will utilize in vivo mouse models, transcriptomic techniques, and advanced intravital imaging
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simulations, statistical mechanics, computer programming (e.g., C++, Python), polymer theory, molecular modeling (e.g., of proteins, nucleic acids, ligands), coarse-grain and polymer model development
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models recapitulating aspects of neural-microglia interactions in neurodegenerative diseases at Ghent University. Lipid accumulation in microglia is a hallmark of neurodegenerative diseases such as
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uniquely conserved—TRIM in animals and polyD/E in eukaryotes—setting them apart from classical PQC mechanisms. We are exploring their molecular mechanisms, their roles in aging and neurodegenerative diseases
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) as models. PXR and CAR transcriptionally regulate cytochrome P450 3A4 (CYP3A4) and CYP3A5-drug-metabolizing enzymes that metabolize more than 50% of clinical drugs, the dysregulation of which
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to numerous preclinical research projects focused on the development of novel molecular magnetic resonance imaging (MRI)-based techniques for early detection, disease phenotyping and monitoring treatment
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Postdoc position: mechanisms of autoimmunity & autoinflammation in inborn errors of immunity (m/f/d)
of the immune dysregulation and clinical translation. The Boztug lab is focusing on the discovery of inborn errors of immunity (IEI) and the dissection of their underlying molecular pathomechanisms. The ultimate