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cellular signaling remains a key challenge in biology and is at the heart of the project. The PhD student will be in charge of the molecular modelling aspects of the multi-scale approaches undertaken by
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resolution. Bioinformatics: Analyzing complex long-read sequencing datasets to identify viral isoforms, detect mutations, and model RNA structures using established and custom pipelines. Molecular virology
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for modelling protein structures and protein-ligand (metabolite) interactions. Using multi-scale molecular models, we aim to predict the structural features of gibberellin (GA) transporters, a key phytohormone
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at the Institute of Biology of the École Normale Supérieure (IBENS), a research centre affiliated with the ENS, the CNRS and the INSERM. The team is internationally renowned in the field of molecular and cellular
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involve the use of expansion microscopy in combination with other super-resolution microscopy approaches such as STED, and molecular biology approaches (CRISPR/Cas9, RNAi), in a human cell culture model
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of the M3i unit UPR9022 at IBMC, “Models of innate immunity in insects” at the Institute of Molecular and Cellular Biology (IBMC). Our team studies the molecular basis underlying interactions between
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-/- strain) mimicking the characteristics of AS, to evaluate the effect of DNM3OS inhibition on disease progression; (2) Cellular models to dissect the signaling pathways and molecular mechanisms underlying
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, the process of host infection remains poorly understood at the molecular level. The fd phage, which specifically infects Escherichia coli, has been used as a model for studying these viruses. This phage
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combining physical chemistry and process engineering. The experimental and theoretical work carried out within this research area has led to an original approach that enables the understanding and modelling
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methodology such as Thermodynamic modelling of multi-component planetary degassing/ingassing, Molecular Dynamic simulations of silicate melts, Petrology of melting of exoplanetary mantles, and the partitioning