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This post is an exciting opportunity which will involve a collaborative project between Astra Zeneca and the neural injury group, NDCN. The aim of this post is to develop human cellular models
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molecular phenotypes of iPSC neurons and glia derived from cells bearing Alzheimers disease risk variants and their isogenic counterparts in order to identify and reverse disease phenotype. About You You will
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interactions. We’re Looking for Someone With: Strong expertise in protein structure prediction, molecular modelling, and docking. Proficiency in LINUX, bash scripting, and high-performance computing environments
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The laboratory of Prof. Simon Davis and Dr. Mafalda Santos at the MRC Weatherall Institute of Molecular Medicine (WIMM), University of Oxford, is seeking a talented and motivated Postdoctoral
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institutions. You will lead the computational aspects of this exciting project by leveraging AI tools such as AlphaFold and developing novel deep generative models and/or large language models. The aim is to
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months. The project involves developing and applying a novel integrated platform to study the chemical molecular mechanisms and signalling consequences of reactive small-molecule metabolites in organ
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models of mechanotransduction. Research projects are highly interdisciplinary, aiming to integrate in vitro biochemical and cell biological techniques with in vivo models and clinical samples. Recent
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novel neuroprotective strategies. You will utilise in vivo rodent models of neurodegeneration in combination with sleep/circadian clock modulators to develop an in-depth understanding of consequences
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experience in stem cell biology. You should have an extensive hands-on experience in culturing human iPSCs and iPSC-derived cellular models as well as experience with molecular cloning and generating knockout
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these bioinformatic experiments. Access to a high-performance computer will be provided. The candidate must be capable of generating complex molecular compound models in silico and using current molecular dynamic