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to “trick” resistant strains into becoming drug-sensitive. This interdisciplinary research combines synthetic biology, molecular biology, and biochemical engineering to pioneer sustainable, non
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language model (LLM)-based genome design tools with bioprocess engineering to create next-generation therapeutic conjugative plasmids. These engineered plasmids will be optimised for industrial-scale
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are conserved across species, including in the mouse, making the aged mouse model a useful means to understand and identify the molecular mechanisms that drive this process (doi: 10.1038/s41586-024-07238-x
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have developed a human ‘brain-on-a-chip’ model that faithfully recapitulates the neurovascular unit, where neurons interface with the vasculature in the brain. You will use CRISPR gene editing
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interdisciplinary training, suitable for candidates from biochemistry, molecular biology, computational biology, chemistry, or data science backgrounds. You will gain experience in: Molecular modeling, QM/MM & MD
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structural biology), Moebius (host–virus evolution, mathematical modelling), and Verkade (correlative microscopy, VolumeEM), the student will be trained in cutting-edge techniques, including cryo-electron
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provide highly sought-after training in the fields of computational molecular modeling, medicinal chemistry, and machine learning. As such, this project is ideal for a candidate with ambitions towards a
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PhD Studentship - EASTBIO - Functional Genomics of Host Determinants in Viral Entry and Transmission
to define proteins affecting viral entry and transmission potential. Research training: The student will gain a comprehensive training that bridges molecular biology, virology, and bioinformatics. Laboratory
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integration into neural circuits to result in functional, restored behaviour. We will use the fruit-fly Drosophila as a model organism for its powerful genetics and molecular cell biology (e.g. CRISPR/Cas9 gene
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. This project will explore PrfA inhibition as an anti-Listeria strategy, building on the host group’s fundamental discoveries on the molecular mechanisms of PrfA regulation. The Vázquez-Boland group recently