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will investigate the mechanisms of skeletal muscle disuse atrophy and test strategies to prevent the loss of muscle mass and function. Experimental models of disuse, including limb immobilisation and bed
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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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record, in many areas of breast cancer including pathology; cell, molecular and radiation biology/radiotherapy; medical oncology/chemotherapy; translational oncology; clinical trials; pre-clinical models
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interdisciplinary training in plant genomics, bioinformatics, and statistical modelling, as well as practical skills in horticulture, experimental design, and data analysis. Working in the De Vega Lab at the Earlham
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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-specific TEM protocol will be used to reveal their subcellular localisation. This work will be done at UEA and IOCAS (Prof. Shan Gao). Objective 2: Using the genetically tractable model diatom Phaeodactylum
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scattering with computer modelling such as molecular dynamics simulations and AI-assisted data mining. The new technical capabilities will help bridge the current gap in biocide development, i.e., to link
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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million individuals has never before been possible in genetics research, not even in model organisms, and promises to transform the way we think about evolution. The student will receive broad training in