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of laboratory infrastructure, including procurement of reagents and equipment, managing incoming scientists and clinicians, performing experiments using molecular biology, virology, cell culture and immunological
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those leading to dementia and neuroinflammation. We have a strong focus on mechanistic dissection of genetic, molecular cellular and neuropathological processes which underlie across the neurodegeneration
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can successfully predict previously-unknown regulators of seed development through functional genetic analysis of conserved, uncharacterised genes in the model seed plant Arabidopsis thaliana
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to: rhizosphere and phyllosphere microbiology microbial evolution molecular and/or structural aspects of plant-microbe or plant-fungal interactions the molecular biology of soil-dwelling bacteria or fungi
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Ubiquitin E3 ligases are central regulators of cellular proteostasis and are directly implicated in neurodegeneration. A detailed understanding of their molecular and structural mechanisms is
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development of mouse models, although this is not requisite. They will be expected to have excellent skills in molecular biology and experience in CRISPR/Cas9 genome editing. Furthermore, they will be expected
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utilize preclinical tumour models, high dimensional techniques including spatial mass spectrometry and immunocytochemistry, alongside complementary state-of-the-art molecular biology approaches to identify
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utilize preclinical tumour models, high dimensional techniques including spatial mass spectrometry and immunocytochemistry, alongside complementary state-of-the-art molecular biology approaches to identify
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to developing new models, techniques and methods as required by their research project. Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
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discoveries (Mehra et al., Science, 2022), this project aims to identify novel genes and regulatory pathways involved in sensing water availability in the model plant Arabidopsis thaliana. We are particularly