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complex socioeconomic, environmental, and molecular data in the context of multigenerational families. · (Co-)developing predictive models based on very large registry, medical, social/environmental
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data in the context of multigenerational families. · (Co-)developing predictive models based on very large registry, medical, social/environmental, and molecular data, aimed at predicting health
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adequately to available treatments. There is a pressing need for novel disease modifying treatments. At present anti-rheumatic drug development still relies on simplified in vitro model systems and on animal
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involves analyzing postmortem human brain tissue from individuals with acquired or genetic obesity to identify molecular signatures linked to obesity and weight loss. Promising microglial and neuronal
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cartilage-on-chip model specifically designed for precision medicine in osteoarthritis (OA), the most common degenerative joint disease affecting more than 1.5 million Dutch citizens. To study OA patient
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-subject clinical and pathological information with morphological and molecular knowledge of induced pluripotent stem cells (iPSC) of PD(D)/DLB patients to identify molecular profiles and drug targets. We
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Vacancies Postdoctoral position: A CARtilage on CHIP model for precision medicine in osteoarthritis (CARCHIP) Key takeaways CARCHIP will combine the expertise of the University of Twente (UTwente
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their involvement in disease resistance under controlled conditions. Our model system is the bacterial pathogen Xanthomonas campestris pv. campestris (Xcc), which causes black rot disease in cabbage
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dilemma that hampers drug development, here, we implemented a translational approach that integrates within-subject clinical and pathological information with morphological and molecular knowledge
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spectrometry, cross-linking mass spectrometry, top-down proteomics and computational modeling. Your work will advance mass spectrometry technology, providing new possibilities to study the structure and function