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insights into MCTP action and ER tubularization at PD, the post-doc will use molecular modeling and dynamics. - undertake simulations - present results in team meetings - present results as scientific
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models, ideally in the context of inflammatory diseases. Proficiency in standard cellular and molecular biology techniques is required, including cell culture, flow cytometry (FACS), Western blotting
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, developing molecular models of electrolytes based on polymers, LiFSI salt, and ionic liquids, in contact with active material surfaces. Simulations will be carried out in confined geometries representative
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/Qualifications Lung physiology Cellular and molecular biology Data analysis Regulations governing animal testing Handling of preclinical mouse models Lung pathophysiology Imagery (confocal and fluorescence
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chloride imaging in cultured hippocampal neurons - Validate 2–3 preselected candidate proteins in vitro and in an in vivo epilepsy model - Neuroscience laboratory - L2 facility, microscopy room Where
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models, flow cytometry, confocal microscopy and unbiased approaches such as single cells transcriptomics, spatial transcriptomics and epigenetics to characterize molecular and cellular mechanisms. Using
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, particularly using reconstructed human skin models that mimic aging or wound-healing conditions. This work takes place in a multidisciplinary framework combining chemistry, biophysics, and tissue engineering
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, and structural biology approaches - the SUMOylation of a key human DNA-repair protein. The project will involve protein expression and purification, interaction assays, structural modelling, and protein
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strong background in molecular biology, biochemistry and cancer biology, and experience in the following areas: Molecular Biology qRT-PCR, Western blotting, co-immunoprecipitation, ChIP-seq, Cut&Tag, AID2
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facilities. Skills/Qualifications PhD in microbiology, molecular biology, or related field Strong experience in bacteriology and molecular mechanisms of pathogenesis Previous experience with insect models and