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cellular signaling remains a key challenge in biology and is at the heart of the project. The PhD student will be in charge of the molecular modelling aspects of the multi-scale approaches undertaken by
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resolution. Bioinformatics: Analyzing complex long-read sequencing datasets to identify viral isoforms, detect mutations, and model RNA structures using established and custom pipelines. Molecular virology
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approach combining cryo-electron microscopy, NMR spectroscopy, and advanced molecular modeling, the research will unravel the molecular architecture and conformational dynamics of pili and their interactions
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for modelling protein structures and protein-ligand (metabolite) interactions. Using multi-scale molecular models, we aim to predict the structural features of gibberellin (GA) transporters, a key phytohormone
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at the Institute of Biology of the École Normale Supérieure (IBENS), a research centre affiliated with the ENS, the CNRS and the INSERM. The team is internationally renowned in the field of molecular and cellular
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French National Research Institute for Agriculture, Food and Environment (INRAE) | Toulouse, Midi Pyrenees | France | 19 days ago
the continuum from virology and immunology to spatial and molecular epidemiology, computer sciences, as well as social and behavioural sciences. Irrespective of their background, all doctoral candidates from
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involve the use of expansion microscopy in combination with other super-resolution microscopy approaches such as STED, and molecular biology approaches (CRISPR/Cas9, RNAi), in a human cell culture model
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of the M3i unit UPR9022 at IBMC, “Models of innate immunity in insects” at the Institute of Molecular and Cellular Biology (IBMC). Our team studies the molecular basis underlying interactions between
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will involve (but not be limited to) applying sophisticated mouse genetic models of cancer and conditional gene targeting, single-cell RNA-seq, spectral flow cytometry, multiplex imaging and spatial
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-/- strain) mimicking the characteristics of AS, to evaluate the effect of DNM3OS inhibition on disease progression; (2) Cellular models to dissect the signaling pathways and molecular mechanisms underlying