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trials (e.g., diet, FMT), and ex vivo gut models enabling advanced multi-omics analyses of these samples. In addition the lab also maintains a large culture collection, partially linked to genomic data
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electrophysiology to translational models, including animal studies and analyses of human tissue samples. This full-stack methodology enables us to directly link molecular channel function with disease phenotypes
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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harnessed for further engineering. The ideal candidate has led a molecular-level scientific research project and has technical expertise in CRISPR, gene transformation, or other genetic tools applied to one
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question: « what makes our brain human ? » (Vanderhaeghen and Polleux, Nat. Rev. Neurosci. 2023). We combine cutting-edge approaches such as pluripotent stem cell models of human corticogenesis, human-mouse