17 molecular-modeling-or-molecular-dynamic-simulation PhD positions at University of Cambridge
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will be based at the University of Cambridge in the Department of Materials Science and Metallurgy as part of the Structural Materials Group. The Structural Materials Group is a diverse and dynamic
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Cambridge Institute (CRUK CI), to investigate the molecular mechanisms of small RNA-mediated chromatin silencing. As a whole, the Hannon laboratory has broad interests that range from discovery research
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automated feeders), and analyse microbiome composition using 16S rRNA and whole-genome sequencing. Statistical modelling will test for links between microbes and host development and fitness.� PROJECT
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: Advanced molecular and protein analysis Mass spectrometry-based imaging Multi-omics technologies Preclinical cardiometabolic animal models They will also gain professional development in data stewardship
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on cell viability and DDR activation in established human cell models. The student will perform CRISPR screens to determine factors that affect resistance/sensitivity and follow these up with mechanistic
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tumours and metastases with the goal to design combinatorial therapeutic approaches. The project will involve the use of genetically complex organoid-derived transplantation mouse models of pancreatic
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of these factors. The work will involve genomic, proteomic and molecular approaches to decipher how these proteins contribute to NEPC and to explore if they can be therapeutically blocked. We aim to understand how
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formation, dynamics and functions of four-stranded DNA G-quadruplex structures and modified DNA bases in the genome (e.g. see Genome Biology, 2025 25, 155; Nature Chemistry, 2025, 17, 875; PNAS, 2024, 12(7
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have or expect to obtain a first or upper second-class degree in a relevant subject from a UK university, or equivalent standard abroad. Prior research experience, for instance in molecular biology
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biology, molecular biophysics, structural biology and particularly genomics. Students will contribute to one or more of our primary research areas below: Our main area of interest is on the structure and